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It is possible that the GluN2B subunit is insensitive to S -nitrosylation, and the synaptic targeting of GluN2B receptors by chronic alcohol exposure renders NO unable to reduce NMDA receptor hyperactivity during withdrawal

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For example, the antioxidant status of blood can be determined by the concentration of protein and lipid peroxidation products as well as the concentration of constituent antioxidants such as vitamins A, C, E, and the carotenoids β-carotene and lycopene [46]